Frequency of prediabetes in individuals with increased adiposity and metabolically healthy or unhealthy phenotypes

Author:

Cefalo Chiara M. A.1ORCID,Riccio Alessia1,Succurro Elena2ORCID,Marini Maria Adelaide3,Fiorentino Teresa Vanessa2,Rubino Mariangela2,Perticone Maria2ORCID,Sciacqua Angela2,Andreozzi Francesco2,Sesti Giorgio1

Affiliation:

1. Department of Clinical and Molecular Medicine University of Rome‐Sapienza Rome Italy

2. Department of Medical and Surgical Sciences University Magna Graecia of Catanzaro Catanzaro Italy

3. Department of Systems Medicine University of Rome‐Tor Vergata Rome Italy

Abstract

AbstractAimsTo utilize the estimated glucose disposal rate (eGDR) index of insulin sensitivity, which is based on readily available clinical variables, namely, waist circumference, hypertension and glycated haemoglobin, to discriminate between metabolically healthy and unhealthy phenotypes, and to determine the prevalence of prediabetic conditions.MethodsNon‐diabetic individuals (n = 2201) were stratified into quartiles of insulin sensitivity based on eGDR index. Individuals in the upper quartiles of eGDR were defined as having metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW) or metabolically healthy obesity (MHO) according to their body mass index, while those in the lower quartiles were classified as having metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW) and metabolically unhealthy obesity (MUO), respectively.ResultsThe frequency of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and IFG + IGT status was comparable among the MHNW, MHOW and MHO groups, while it increased from those with MUNW status towards those with MUOW and MUO status. As compared with participants with MHNW, the odds ratio of having IFG, IGT, or IFG + IGT was significantly higher in participants with MUOW and MUO but not in those with MUNW, MHOW and MHO, respectively.ConclusionsA metabolically healthy phenotype is associated with lower frequency of IFG, IGT, and IFG + IGT status across all body weight categories.

Funder

Sapienza Università di Roma

European Foundation for the Study of Diabetes

Ministero dell'Università e della Ricerca

Società Italiana di Medicina Interna

Publisher

Wiley

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