Affiliation:
1. Center for Genetic Epidemiology and Genomics School of Public Health, Medical College of Soochow University Suzhou Jiangsu China
2. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Soochow University Suzhou Jiangsu China
3. Center of Osteoporosis Kunshan Hospital of Traditional Chinese Medicine Kunshan Jiangsu China
4. Cambridge‐Suda Genomic Resource Center, Jiangsu Key Laboratory of Neuropsychiatric Diseases Medical College of Soochow University Suzhou Jiangsu China
Abstract
ABSTRACTBackgroundThis study aimed to investigate the effect of systemic inflammation, assessed by high sensitivity C‐reactive protein (hs‐CRP) levels, on prediabetes progression and regression in middle‐aged and older adults based on the China Health and Retirement Longitudinal Study (CHARLS).MethodsParticipants with prediabetes from CHARLS were followed up 4 years later with blood samples collected for measuring fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c). The level of hs‐CRP was assessed at baseline and categorized into tertiles (low, middle, and high groups). Prediabetes at baseline and follow‐up was defined primarily according to the American Diabetes Association (ADA) criteria. Logistic regression models were used to estimate the odds ratios (ORs) and confidence intervals (CIs). We also performed stratified analyses according to age, gender, BMI, the presence of hypertension, and the disease history of heart disease and dyslipidemia and sensitivity analyses excluding a subset of participants with incomplete data.ResultsOf the 2,874 prediabetes included at baseline, 834 participants remained as having prediabetes, 146 progressed to diabetes, and 1,894 regressed to normoglycemia based on ADA criteria with a 4 year follow‐up. After multivariate logistics regression analysis, prediabetes with middle (0.67–1.62 mg/L) and high (>1.62 mg/L) hs‐CRP levels had an increased incidence of progressing to diabetes compared with prediabetes with low hs‐CRP levels (<0.67 mg/L; OR = 1.846, 95%CI: 1.129–3.018; and OR = 1.632, 95%CI: 0.985–2.703, respectively), and the incidence of regressing to normoglycemia decreased (OR = 0.793, 95%CI: 0.645–0.975; and OR = 0.769, 95%CI: 0.623–0.978, respectively). Stratified analyses and sensitivity analyses showed consistent results.ConclusionsLow levels of hs‐CRP are associated with a high incidence of regression from prediabetes to normoglycemia and reduced odds of progression to diabetes.
Funder
National Natural Science Foundation of China
Science and Technology Program of Suzhou
Subject
General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine