A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay-Reference-Cited by-同舟云学术

A new cell culture-based assay quantifies vitamin K 2,3-epoxide reductase complex subunit 1 function and reveals warfarin resistance phenotypes not shown by the dithiothreitol-driven VKOR assay

Published:2013-05 Issue:5 Volume:11 Page:872-880
ISSN:1538-7933
Container-title:Journal of Thrombosis and Haemostasis
language:en
Short-container-title:J Thromb Haemost

Author:

Fregin A.¹,Czogalla K. J.²,Gansler J.³,Rost S.¹,Taverna M.⁴,Watzka M.²,Bevans C. G.²,MüLler C. R.¹,Oldenburg J.²

Affiliation:

1. Institute of Human Genetics; University of Würzburg; Würzburg Germany

2. Institute of Experimental Haematology and Transfusion Medicine; University Clinic Bonn; Bonn Germany

3. Institute for Biochemistry; Medical School; Justus Liebig University; Giessen Germany

4. Metabolic Biochemistry; Department of Medicine; Adolf Butenandt Institute; Ludwig Maximilian University of Munich; Munich Germany

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.12185/fullpdf

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3. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2;Rost;Nature,2004

4. Identification of the gene for vitamin K epoxide reductase;Li;Nature,2004

5. Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2;Chu;Proc Natl Acad Sci USA,2006

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