Abstract
A synthesis of d,l-prostaglandin E2 (PGE2) methyl ester is described. Two new acetylenic prostaglandins, methyl 11α,15-dihydroxy-9-oxo-prost-5-yn-13-enoate and its C15 epimer, were obtained as intermediates in this synthesis. A solvolytic rearrangement of a bicyclo[2.1.0]hexane to a cyclopentane vinyl system is discussed.
Publisher
Canadian Science Publishing
Cited by
33 articles.
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