Author:
Rupar C. Anthony,Albo Susan,Whitehall Jeffery D.
Abstract
The subcellular distribution of α-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in α-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of α-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states.Key words: α-tocopherol, lysosomes, mitochondria, membrane.
Publisher
Canadian Science Publishing
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
18 articles.
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