A simple and efficient metal free, additive, or base free dehydrogenation of tetrahydroisoquinolines using oxygen as a clean oxidant-Reference-Cited by-同舟云学术

A simple and efficient metal free, additive, or base free dehydrogenation of tetrahydroisoquinolines using oxygen as a clean oxidant

Published:2021-03 Issue:3 Volume:99 Page:311-316
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Ramu Shanmugam¹¹,Baskar Baburaj¹¹

Affiliation:

1. Laboratory of Sustainable Chemistry, Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chengalpet (Dt), Tamilnadu 603 203, India.

Abstract

Metal free dehydrogenation of various substituted tetrahydroisoquinolines via a simple and convenient metal free, atom economical route for the synthesis of corresponding isoquinolines under oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described. Metal free dehydrogenation was carried out without the use of additive or base. A scope of the methodology was demonstrated for a number of aryl and heteroaryl substitutions present at C1 position and ester moiety at C3 position and was found to be good substrates. Substituted isoquinolines (3a–3h) and their esters (3i–3m) were synthesized in very good to excellent yields.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

https://cdnsciencepub.com/doi/pdf/10.1139/cjc-2020-0295

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