THE COMPETITIVE INHIBITION OF AMINE OXIDASE WITH SPECIAL REFERENCE TO THE CARCINOID SYNDROME

Author:

Fellman J. H.,Roth Esther S.

Abstract

This report deals with an in vitro study of the competitive inhibition of monoamine oxidase by aromatic amines which are substrates for the enzyme. The metabolism of normetanephrine by mitochondrial monoamine oxidase was demonstrated to be competitively inhibited by 5-hydroxytryptamine, and in a similar fashion the oxidation of 5-hydroxytryptamine was shown to be inhibited by normetanephrine. An in vivo demonstration of this effect was contrived as a model of the carcinoid syndrome, and the pattern of the urinary metabolites was examined in rats before and after the intraperitoneal injection of 5-hydroxytryptamine. The data reveal a distortion in pattern of the urinary metabolites of the catecholamines consistent with the idea of an in vivo inhibition of monoamine oxidase by the appearance of a massive amount of 5-hydroxytryptamine. Evidence from a patient afflicted with carcinoid which suggests that this phenomenon operates in this clinical condition and that it may also account for the epinephrine triggering of the flushing syndrome is presented.

Publisher

Canadian Science Publishing

Subject

General Medicine

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