Cu(II) complexes of 2-methoxy-5-sulfamoylbenzoic acid and 2-aminopyridine derivatives: Synthesis, characterization and antimicrobial activity

Abstract

Three novel mixed ligand Cu(II) complexes {[Cu(sba)2(X)2].2H2O, X = 2a3NO24mp for 1, 2a5Clp for 2, 2a5NO2p for 3} obtained from 2-methoxy-5-sulfamoylbenzoic acid (Hsba) with 2-amino-3-nitro-4-methylpyridine (2a3NO24mp), 2-amino-5-chloropyridine (2a5Clp) and 2-amino-5-nitropyridine (2a5NO2p), respectively, have been prepared. The structures of 1-3 FT-IR, AAS, UV, molar conductivity, magnetic susceptibility, and charge balance as suggested by previous studies have been characterized. According to spectroscopic findings, the structures of 1-3 can be postulated as tetrahedral complexes. Furthermore, all compounds have been screened for their antibacterial and antifungal activities against Pseudomonas aeruginosa (ATCC 27853), Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (NRRL B-767), Bacillus subtilis, Escherichia coli (ATCC25922) and Listeria monocytogenes (ATCC 7644) bacteria and Candida albicans (F89) yeast. The outcomes are contrasted with those of the control substances (Fluconazole as antifungal and Cefepime, Levofloxacin, and Vancomycin as antibacterial agents). The best activity values of the compounds are Cu(Ac)2.2H2O for S. aureus bacteria, 2a5NO2p for E. coli bacteria, 2 for P. aeruginoa bacteria, Hsba, 2a3NO24mp and 2a5NO2p for L. monocytogenes bacteria, Cu(Ac)2.2H2O, 2a3NO24mp, 2a5Clp, 2a5NO2p and 2 for E. faecalis bacteria, all compounds (except 3) for B. subtilis bacteria, and 2a5NO2p and 1 were observed for C. albicans yeast.