Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model-Reference-Cited by-同舟云学术

Morphostructural changes in the brain of experimental animals after using mesenchymal stem cells in the temporomandibular joint inflammation model

Published:2023-09-01 Issue:3 Volume:20 Page:216-225
ISSN:2524-2350
Container-title:Proceedings of the National Academy of Sciences of Belarus, Medical series
language:
Short-container-title:Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

Author:

Pashkevich S. G.¹,Rubnikovich S. P.²,Kuznetsova T. E.¹,Kuzmenko E. V.³,Mironova G. P.¹,Tikhonovich O. G.¹,Gladkova Zh. A.¹,Zhogal K. N.¹,Serdyuchenko N. S.¹,Grishchenkov A. S.³

Affiliation:

1. Institute of Physiology of the National Academy of Sciences of Belarus

2. Belarusian State Medical University; Belarusian Medical Academy of Postgraduate Education

3. Belarusian Medical Academy of Postgraduate Education

Abstract

The article presents the results of structural and functional transformations in cerebellum, trigeminal nuclei, and hippocampus of male Wistar rats against the background of injection of mesenchymal stem cells (MSCs) into Meckel’s space in the temporomandibular joint (TMJ) inflammation model.The aim of the study was to clarify the effect of MSCs injections into Meckel’s space on the morphostructural features of cerebellum, trigeminal nuclei, and hippocampus in the TMJ inflammation model.Injecting the mesenchymal stem cells into Meckel’s space in an inflammatory model of the right lower temporomandibular joint promotes the structure restoration of the ganglionic layer of the cerebellum, the spinal nuclei of the trigeminal nerve, and the hippocampus of rats by the 28th day. This is manifested in increasing the neuronal density, decreasing the neurodegeneration index, and in activating glia elements.

Publisher

Publishing House Belorusskaya Nauka

Subject

General Medicine

Reference21 articles.

1. Jokubauskas L., Baltrušaitytė A. Relationship between obstructive sleep apnoea syndrome and sleep bruxism: a systematic review. Journal of Oral Rehabilitation, 2017, vol. 44, no. 2, pp. 144–153. https://doi.org/10.1111/joor.12468

2. Li D., Kuang B., Lobbezoo F., de Vries N., Hilgevoord A., Aarab G. Sleep bruxism is highly prevalent in adults with obstructive sleep apnea: a large-scale polysomnographic study. Journal of Clinical Sleep Medicine, 2023, vol. 19, no. 3, pp. 443–451. https://doi.org/10.5664/jcsm.10348

3. Rubnikovich S. P., Baradina I. N., Denisova Yu. L., Samuilov I. V., Davydov M. V., Kul’chitskii V. A. Analysis of the functional state of the muscles of the maxillofacial region in dental patients with signs of bruxism in combination with obstructive sleep apnea. Doklady Natsional’noi akademii nauk Belarusi = Doklady of the National Academy of Sciences of Belarus, 2020, vol. 64, no. 3, pp. 341–349 (in Russian).

4. Zhao Y., Wang J., Li M., Ma T., Zhang X., Xu X., Zeng M., Peng Y. The influence of trigeminocardiac reflex on post-operative cardiac adverse events in patients undergoing cerebellopontine angle tumor resections: a case-control study. World Neurosurgery, 2023, vol. 172, pp. e291–e298. https://doi.org/10.1016/j.wneu.2023.01.010

5. González A. G., Montero J., Polo C. G. Sleep apnea-hypopnea syndrome and sleep bruxism: A systematic review. Journal of Clinical Medicine, 2023, vol. 12, no. 3, art. 910. https://doi.org/10.3390/jcm12030910