Synthesis of functional derivatives of chlorine-substituted isothiazoles.
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Published:2024-09-03
Issue:3
Volume:60
Page:215-221
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ISSN:2524-2342
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Container-title:Proceedings of the National Academy of Sciences of Belarus, Chemical Series
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language:
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Short-container-title:Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk
Author:
Margun E. N.1, Kolesnik I. A.1, Akishina E. A.1, Dikusar E. A.1, Logvinenko N. A.2, Volchkov N. S.2, Potkin V. I.1
Affiliation:
1. Institute of Physical Organic Chemistry of the National Academy of Sciences of Belarus 2. RUDN University
Abstract
Optimal procedures have been developed for the synthesis of substituted isothiazoles containing an active chlorine atom in position 5 of the heterocycle and various functional groups in position 3: carboxyl, hydroxymethyl, aldehyde. Based on these methods, previously undescribed compounds were obtained: 5-morpholino-substituted 3-hydroxymethyl-4- chloroisothiazole, 4-chloroisothiazole-3-carboxylic acid and its methyl ester. The resulting substances are reactive building blocks for organic synthesis of compounds with a high potential for biological activity.
Publisher
Publishing House Belorusskaya Nauka
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