Pyrimethamine as a Potential Pharmacological Chaperone for Late-onset Forms of GM2 Gangliosidosis
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference55 articles.
1. The Protein Activator Specific for the Enzymic Hydrolysis of GM2Ganglioside in Normal Human Brain and Brains of Three Types of GM2Gangliosidosis
2. Crystallographic Structure of Human β-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis
3. Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay–Sachs Disease
4. A single site in human β-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside
5. Direct Determination of the Substrate Specificity of the α-Active Site in Heterodimeric β-Hexosaminidase A
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