Method for Assessing Local Metabolism of Mammary Tumors Based on Multimodal Optical Technology

Abstract

Introduction. Breast cancer (BC) is the most common malignant tumor in women worldwide. It amounts more than 16 % of all cases of malignant neoplasms in women. Modern advances in radiological methods of breast tumors detection significantly increased the number of non-palpable neoplasms revealed during examinations, while further progress requires the development of improved minimally invasive techniques for obtaining biopsy material from breast tumors using tools of navigational controls. An approach with high potential for direct evaluation of local tumor metabolism consists in complementary use of fluorescence spectroscopy and diffuse reflectance spectroscopy.Purpose: Evaluation of the effectiveness of a new complementary approach for the diagnosis of the metabolic status of breast tumors in patients suspicious for breast cancer.Material and methods. This article presents the results of the examination of 21 patients with breast neoplasms who, in addition to standard examination methods, including ultrasound, X-ray mammography, puncture biopsy and trepanobiopsy, were subject to evaluation of local tumor metabolism with complementary employment of fluorescence spectroscopy and diffuse reflectance spectroscopy .Results. It has been established that the malignant breast tumors have lower saturation values compared with both benign tumors and the surrounding healthy tissue: StO2(BC) = 6,6 % [5,7-24,8 %]; 79,0 % [77,6-84,4 %], StO2(fibroadenoma) = 66,3 %[43,7-74,8 %]. It is also found that the malignant tumors have higher values of NADPH compared with the benign tumors (INAD(P) H(BC) = 6157 a.u. [2188-8814 a.u.]; INADH (fibroadenoma) = 2962 a.u. [1924-4301 a.u. ]).Conclusion. The new method of the diagnosis of the local breast tumor metabolism can be further used to improve the results of targeted biopsies under ultrasound control and to assess the therapeutic pathomorphosis of BC. To evaluate the effectiveness of this diagnostic method, it is necessary to continue the study with a larger number of patients in order to obtain statistically reliable data.