Therapeutic Effect of <i>Withania somnifera</i> (Ashwagandha) on Depression: A comprehensive review

Abstract

Ashwagandha (<i>Withania somnifera</i>), which is widely used in Ayurveda and other system of medicine, is best known for its ability to reduce depression and associated problems. Notably, important constituents of the body such as enzymes are intimately associated with the chemicals present in plants; hence supplementation is necessary to maintain overall health. In this study, reports of experimental studies were collected primarily from various scientific sources like Scopus, Springer, PubMed, Google Scholar etc. The findings of the review suggested that AS extract and its phytoconstituents significantly reduced depression and also modulated oxidative stress and inflammation which play a major role in neurological disorders including depression. The growing amount of research on ashwagandha emphasizes its potential as a useful natural depression remedy. However, further preclinical and clinical research is necessary to substantiate present observations to establish better methods for assessing the ashwagandha safety, effectiveness, bioavailability, purity, and precise mechanisms of action.