Affiliation:
1. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College
2. University of Electronic Science & Technology of China
3. Tiangong University
4. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College
Abstract
The human lung was quantified and visualized by photon transport in this paper. A Monte Carlo (MC) simulation of voxelized media was used with the visible Chinese human (VCH). This study theoretically explored the feasibility of non-invasive optical detection of pulmonary hemodynamics, and investigated the optimal location of the light source in the lung photon migration and optimized the source-detector distance. The light fluence intensity showed that the photon penetration depth was 6-8.4 mm in the human lung. The optimal distance from the light source to the detector was 2.7-2.9 cm, but the optimal distance of the superior lobe of right lung was 3.3-3.5 cm. We then conducted experiments on diffuse light reflectance using NIRS on 14 volunteers. These measurements agree well with the simulation results. All the results demonstrated the great potential of non-invasive monitoring of pulmonary hemodynamics and contribute to the study of human lungs in the biomedical optics community
Funder
Basic Research Program for Beijing-Tianjin-Hebei Coordination under Grant
Program of Chinese Institute for Brain Research in Beijing
Tianjin Outstanding Youth Fund Project
Sichuan Science and Technology Program
Medical & Health Innovation Project
National Natural Science Foundation of China
Subject
Atomic and Molecular Physics, and Optics,Biotechnology
Cited by
6 articles.
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