Panretinal handheld OCT angiography for pediatric retinal imaging

Author:

Ni ShuibinORCID,Liang Guangru BenORCID,Ng Ringo,Ostmo Susan,Jia YaliORCID,Chiang Michael F.1,Huang DavidORCID,Skalet Alison H.2,Young Benjamin K.,Campbell J. Peter,Jian Yifan

Affiliation:

1. National Institutes of Health

2. Oregon Health & Science University

Abstract

Comprehensive visualization of retina morphology is essential in the diagnosis and management of retinal diseases in pediatric populations. Conventional imaging techniques often face challenges in effectively capturing the peripheral retina, primarily due to the limitations in current optical designs, which lack the necessary field of view to characterize the far periphery. To address this gap, our study introduces a novel ultra-widefield optical coherence tomography angiography (OCTA) system. This system, specifically tailored for pediatric applications, incorporates an ultrahigh-speed 800 kHz swept-source laser. The system’s innovative design achieves a 140° field of view while maintaining excellent optical performance. Over the last 15 months, we have conducted 379 eye examinations on 96 babies using this system. It demonstrates marked efficacy in the diagnosis of retinopathy of prematurity, providing detailed and comprehensive peripheral retinal angiography. The capabilities of the ultra-widefield handheld OCTA system in enhancing the clarity and thoroughness of retina vascularization assessments have significantly improved the precision of diagnoses and the customization of treatment strategies. Our findings underscore the system’s potential to advance pediatric ophthalmology and broaden the scope of retinal imaging.

Funder

National Institutes of Health

Research to Prevent Blindness

Bright Focus Foundation

Knights Templar Eye Foundation

National Eye Institute

Intramural Research Program

Publisher

Optica Publishing Group

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