Septic shock in adults: guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”

Author:

Kirov M. Yu.1ORCID,Kuzkov V. V.1ORCID,Protsenko D. N.2ORCID,Shchegolev A. V.3ORCID,Babaev M. A.4ORCID,Belotserkovskiy B. Z.2ORCID,Bykov A. O.5ORCID,Gritsan A. I.6ORCID,Kulabukhov V. V.7ORCID,Kulikov A. V.8ORCID,Kupreichik V. L.9ORCID,Lakhin R. E.10ORCID,Lebedinskii K. M.11ORCID,Rey S. I.12ORCID,Rudnov V. A.8ORCID,Smetkin Alexey A.1ORCID,Surkov M. V.3ORCID,Shifman E. M.13ORCID,Shlyapnikov S. A.14ORCID,Yarustovsky M. B.15ORCID,Zabolotskikh I. B.16ORCID

Affiliation:

1. Northern State Medical University, Arkhangelsk, Russia

2. Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia; Moscow’s Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

3. Military Medical Academy, St. Petersburg, Russia

4. Petrovsky National Research Centre of Surgery, Moscow, Russia

5. Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia; Moscow’s Multidisciplinary Clinical Center “Kommunarka”, Moscow, Rus

6. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Krasnoyarsk regional center of medical education, Krasnoyarsk, Russia

7. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

8. Ural State Medical University, Yekaterinburg, Russia

9. Moscow’s Multidisciplinary Clinical Center “Kommunarka”, Moscow, Russia

10. Military Medical Academy, St. Petersburg, Russia; Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia

11. North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia; Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia

12. N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia; Research Institute for Healthcare Development and Medical Management of Moscow Healthcare Department, Moscow, Russia

13. Moscow Regional Research and Clinical Institute, Moscow, Russia

14. St. Petersburg Research Institute of Emergency Medicine named after I.I. Dzhanelidze, St. Petersburg, Russia

15. A.N. Bakulev National Medical Research Сеnter for Cardiovascular Surgery of the Russian Ministry of Health, Moscow, Russia

16. Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia; Kuban State Medical University, Krasnodar, Russia; Regional Clinical Hospital No 2, Krasnodar, Russia

Abstract

The paper represents the clinical guidelines for septic shock in adults, approved by the All-Russian public organization “Federation of anesthesiologists and reanimatologists” in 2023. Septic shock is a widespread condition with a high mortality rate. The recommendations cover the issues of etiology, pathogenesis, clinical signs and symptoms, methods of laboratory and instrumental diagnosis of septic shock. The clinical guidelines present initial therapy for septic shock, including approaches to vasopressor and inotropic therapy, recommendations for choosing antibacterial drugs, fluid and adjuvant therapy. The issues of surgical treatment of the infection are discussed. The article contains the criteria for the quality of medical care for the adult patients with septic shock and algorithms for the decision making in the diagnosis and intensive care of patients with septic shock.

Publisher

Practical Medicine Publishing House

Subject

Law,Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medical Services

Reference320 articles.

1. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

2. Hemodynamic variables related to outcome in septic shock

3. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

4. Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017

5. Яковлев С.В., Суворова М.П., Белобородов В.Б. и др. Распространенность и клиническое значение нозокомиальных инфекций в лечебных учреждениях России: исследование ЭРГИНИ. Антибиотики и химиотерапия. 2016; 61(5–6): 32–42. [Yakovlev S.V., Suvorova M.P., Beloborodov V.B. et al. Multicentre Study of the Prevalence and Clinical Value of Hospital-Acquired Infections in Emergency Hospitals of Russia: ERGINI Study. Antibiotics and Chemotherapy. 2016; 61(5–6): 32–42. (In Russ)]

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