Abstract
The author’s point of view is presented, according to which, formulated back in the 80s of the last century by Yu.M. Lopukhin et al., the cholesterol theory of aging and death is now often misunderstood by many biologists and physicians. It is emphasized that this theory prioritized not the well-known role of cholesterol (CS) in metabolic processes, but its structural role in the plasma membrane of the cell. It was assumed that an increase in the microviscosity of the cell membrane due to the accumulation of CS in it leads to a deterioration in the transfer of external signals and nutrients to the cell, as well as to a decrease in the activity of membrane enzymes. This, according to the authors, triggers the occurrence of “senile” changes in cells, tissues and organs, and then in the entire multicellular organism, which ultimately leds to an increase in the probability of its death, that is, to aging. At the same time, the content of CS (mainly, of considered to be especially “bad” CS of low density lipoproteins) in serum was assigned only a minor role, because its increase is not at all necessary, according to the authors of the concept, leads to adverse changes in the body. This paper briefly discusses the evolution of ideas about the possible role of CS in aging and the development of various age-related pathologies, mainly cardiovascular diseases and mental disorders. Experimental data on the effect of liposomes containing both normal and oxidized CS on the proliferative activity of cultured cells are analyzed. The data of longitudinal studies are considered, suggesting that, paradoxically, it is people with elevated levels of CS in the blood plasma who live to an advanced age. At the same time, the consumption of large amounts of food rich in CS may not affect the health of some patients. It is noted that a number of studies indicate the absence of a causal relationship between the level of CS in serum and the occurrence of atherosclerotic changes. It is emphasized that CS is a very important compound for our body, without which cell proliferation and, as a result, normal regeneration are impossible. It is noted that there is a continuously increasing amount of data on the negative role of statins in the formation of age-related pathology, especially in people of older age groups. It is concluded that at present it becomes obvious that there is a need for a significant reappraisal (using the systems approach) of ideas about the possible role of CS in aging, the development of atherosclerosis and other age-related diseases, as well as dementias due to various causes, including Alzheimer’s disease.