The Role of Sleep Deprivation in Arrhythmias

Author:

Wang Wenlong1,Yin Hongpeng1,Sun Ge1,Zhang Junpei1,Sun Jingmei1,Mbabazi Nadine2,Zou Lina1,Li Bin1,Lin Pengqi1,Pei Quanwei1,Wang Xin1,Wang Penghe1,Ji Xuanrui1,Qu Xiufen1,Yin Dechun1

Affiliation:

1. Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China

2. Department of Cardiology, King Faisal Hospital, Kigali, Rwanda

Abstract

Sleep is essential to the normal psychological and physiological activities of the human body. Increasing evidence indicates that sleep deprivation is associated with the occurrence, development, and poor treatment effects of various arrhythmias. Sleep deprivation affects not only the peripheral nervous system but also the central nervous system, which regulates the occurrence of arrhythmias. In addition, sleep deprivation is associated with apoptotic pathways, mitochondrial energy metabolism disorders, and immune system dysfunction. Although studies increasingly suggest that pathological sleep patterns are associated with various atrial and ventricular arrhythmias, further research is needed to identify specific mechanisms and recommend therapeutic interventions. This review summarizes the findings of sleep deprivation in animal experiments and clinical studies, current challenges, and future research directions in the field of arrhythmias.

Publisher

Compuscript, Ltd.

Subject

General Medicine

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