Outcomes of hypofractionation for early-stage glottic carcinoma

Abstract

ABSTRACT Background: Our goal is to evaluate hypofractionation in early-stage glottic carcinoma of a single center in line with randomized trials. Materials and Methods: Between June 2016 and January 2021, 33 early glottic carcinoma patients treated with IMRT (intensity-modulated radiotherapy) in the Radiation Oncology Department were analyzed. Descriptive statistics and survival analysis were applied. Survival analysis and curves were done via the Kaplan–Meier method. Survival curves were analyzed due to the T stage. Log-rank test was used for the analysis of T stage survival curves. Results: Twenty (60.1%) patients were T1 whereas six (18.2%) and seven (21.2%) were Tis. 56.25 Gy, 63 Gy, and 65.25 Gy were delivered to the patients with Tis, T1, and T2, respectively. All groups were treated with 2.25 Gy per fraction. T2 stage had lesser DFS (disease-free survival) compared to Tis and T1 stage and it was statistically significant (P = 0.035). Conclusion: Hypofractionation with 2.25 Gy per fraction may be standard for early glottic carcinoma with similar results compared to microsurgery and conventional fractionation radiotherapy.