Green Synthesis of Zinc Oxide Nanoparticles Using Currant Extracts and Study of Protective against Liver Necrosis of Rat

Abstract

Abstract Aim: The goal of the current research was to synthesize zinc oxide nanoparticles (ZnONPs) via a simple, cheap, and eco-friendly method as an efficient antioxidant agent. Materials and Methods: ZnONPs are synthesized by reduction of zinc acetate dehydrate using extract of black currant (BC) as reductant. The characterization of stability, size, morphology, and the surface function groups present on synthesized ZnOBCNPs was achieved by Fourier transform infra red, scanning electron microscopy, and X-ray diffraction. In addition, the research included investigating the protective effect of prepared ZONPS on oxidative-stressed rats and evaluating its effectiveness in reducing free radical-induced damage by tracking the concentrations of liver enzymes and blood lipid profiles of rats. Results: The results showed that ZONPS has a positive, beneficial effect in the protection of the rat tissues and ameliorating side effects of oxidative stress. Conclusions: ZONPS can be produced in a simple way, quickly, and in an environmentally friendly manner without the use of hazardous reagents. In this method, zinc acetate dehydrate is reduced with an aqueous solution of BC. The ZONPS, thus produced, can be used as a tissue protectant against oxidative stress. The results showed that the concentrations of liver enzymes and blood lipid profile were stable within normal values in rats exposed to oxidative stress and treated with the prepared ZONPS solution. This indicates that the prepared nanoparticles reduced the harmful effect of oxidative stress through several proposed mechanisms mentioned previously.