Factors affecting corneal deformation amplitude measured by Corvis ST in eyes with open-angle glaucoma

Author:

Pradhan Zia S1,Sreenivasaiah Shruthi1,Deshmukh Sujit1,Mangala Lavi1,Shroff Sujani1,Devi Sathi1,Webers Carroll AB2,Rao Harsha L23

Affiliation:

1. Department of Glaucoma, Narayana Nethralaya, Bangalore, Karnataka, India

2. Department of Glaucoma, University Eye Clinic Maastricht, University Medical Center, Maastricht, The Netherlands

3. Department of Glaucoma , Narayana Nethralaya, 63, Bannerghatta Road, Hulimavu, Bangalore, Karnataka, India

Abstract

Abstract Purpose: To evaluate the factors affecting corneal deformation amplitude (DA) measured using Corvis ST in eyes with open-angle glaucoma. Methods: This prospective, longitudinal study included 48 eyes with open-angle glaucoma who required additional intraocular pressure (IOP)-lowering drops. All eyes underwent a complete eye examination at baseline, including a Corvis ST, which was repeated 4–8 weeks after the change in therapy. Factors affecting the corneal biomechanics, namely the DA, were determined using mixed effect models. Results: The mean age of the cohort was 65.0 ± 7.9 years. The mean IOP reduced from 23.4 ± 5.4 mmHg to 17.9 ± 5 mmHg after the change in glaucoma treatment (P < 0.001). The DA increased from 0.89 ± 0.16 mm to 1.00 ± 0.13 mm after IOP reduction (P < 0.001). On mixed effect model analysis, IOP (−0.02 ± 0.001, P < 0.001) and corneal pachymetry (−0.0003 ± 0.0001, P = 0.02) affected the change in the DA. Conclusion: IOP and corneal pachymetry affect the DA and must be accounted for when using Corvis ST to evaluate corneal biomechanics in glaucoma.

Publisher

Medknow

Subject

Ophthalmology

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