Expression level of interferon-stimulated genes PKR, OAS1, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients: A retrospective study-Reference-Cited by-同舟云学术

Expression level of interferon-stimulated genes PKR, OAS1, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients: A retrospective study

Published:2024-06 Issue:3 Volume:13 Page:111-115
ISSN:2221-6189
Container-title:Journal of Acute Disease
language:en
Short-container-title:

Author:

Maskouni Elham Jafari¹,Abbasi Samaneh²,Mousavi Elham¹,Najafimemar Zahra³,Arabzadeh Ali Mohammad¹,Farrokhnia Mehrdad⁴,Ebrahimi Saeedeh¹

Affiliation:

1. Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2. Abadan University of Medical Sciences, Abadan, Iran

3. Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran

4. Department of Internal Medicine, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Objective: To explore expression level of interferon-stimulated genes PKR, OASI, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients. Methods: In this study, changes in the expression of four interferon-stimulated genes (ISGs), including PKR, OASI, MX1, and ISG15, in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method. Results: OASI, MX1, PKR, and ISG15 were differently expressed in COVID-19 patients with different severity. The results showed that the expression of OASI, MX1, PKR, and ISG15 genes was significantly (P=0.001) lower in severe patients. Conclusions: Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.

Publisher

Medknow

Reference22 articles.

1. SARS-CoV-2 and Coronavirus Disease 2019: What we know so far;Rabi;Pathogens,2020

2. SARS-CoV-2: Structure, biology, and structure-based therapeutics development;Wang;Front Cell Infect Microbiol,2020

3. The outbreak of COVID-19: An overview;Wu;J Chin Med Assoc,2020

4. Covid-19: Risk factors for severe disease and death;Jordan;BMJ,2020

5. The effect of age and gender on the severity of coronavirus infection;Yahya;Mosul J Nurs,2022