Expression level of interferon-stimulated genes PKR, OAS1, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients: A retrospective study

Author:

Maskouni Elham Jafari1,Abbasi Samaneh2,Mousavi Elham1,Najafimemar Zahra3,Arabzadeh Ali Mohammad1,Farrokhnia Mehrdad4,Ebrahimi Saeedeh1

Affiliation:

1. Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2. Abadan University of Medical Sciences, Abadan, Iran

3. Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran

4. Department of Internal Medicine, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Objective: To explore expression level of interferon-stimulated genes PKR, OASI, MX1, and ISG15 in peripheral blood mononuclear cells of COVID-19 patients. Methods: In this study, changes in the expression of four interferon-stimulated genes (ISGs), including PKR, OASI, MX1, and ISG15, in peripheral blood mononuclear cells of 45 COVID-19 patients with different severities were evaluated by real-time PCR method. Results: OASI, MX1, PKR, and ISG15 were differently expressed in COVID-19 patients with different severity. The results showed that the expression of OASI, MX1, PKR, and ISG15 genes was significantly (P=0.001) lower in severe patients. Conclusions: Weak and defective IFN response and subsequent disruption of ISGs may be associated with COVID-19 severity.

Publisher

Medknow

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