Glycolysis and acute lung injury: A review

Author:

Yi Yang123,Chen Jun4,Li Nan123,Huang Yue123,Peng Jichao123,Liu Xiaoran123

Affiliation:

1. College of Emergency Trauma, Hainan Medical University, Haikou, China

2. Key Laboratory of Hainan Trauma and Disaster Rescue, the First Affiliated Hospital of Hainan Medical University, Haikou, China

3. Key Laboratory of Emergency and Trauma Ministry of Education, Hainan Medical University, Haikou, China

4. Danzhou People's Hospital, Danzhou, China

Abstract

Acute lung injury is featured as diffuse pulmonary edema and persistent hypoxemia caused by lung or systemic injury. It is believed that these pathological changes are associated with damage to the alveolar epithelium and vascular endothelium, recruitment of inflammatory cells, and inflammatory factor storms. In recent years, the metabolic reprogramming of lung parenchymal cells and immune cells, particularly alterations in glycolysis, has been found to occur in acute lung injury. Inhibition of glycolysis can reduce the severity of acute lung injury. Thus, this review focuses on the interconnection between acute lung injury and glycolysis and the mechanisms of interaction, which may bring hope for the treatment of acute lung injury.

Publisher

Medknow

Subject

General Medicine

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