Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma

Author:

Liu Jin-man,Chen Jun-mei,Lin Ming-jun,Wu Fan-chang,Ma Cui-ru,Zuo Xue,Yu Wen-qian,Huang Ming-jun,Fang Jian-song,Li Wei-rong,Wang Qi,Liang YongORCID

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference33 articles.

1. Drug metabolism in the liver;Almazroo;Clin. Liver Dis.,2017

2. The mechanisms of bushen-yizhi formula as a therapeutic agent against Alzheimer's disease;Cai;Sci. Rep.,2018

3. Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition;Chen;Drug Metab. Rev.,2021

4. Osthole inhibits triple negative breast cancer cells by suppressing STAT3;Dai;J. Exp. Clin. Canc. Res.,2018

5. The in vitro and in vivo anti-inflammatory effect of osthole, the major natural coumarin from Cnidium monnieri (L.) Cuss, via the blocking of the activation of the NF-kappaB and MAPK/p38 pathways;Fan;Phytomedicine,2019

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