Potentiation of flutamide-induced hepatotoxicity in mice by Xian-Ling-Gu-Bao through induction of CYP1A2

Author:

Ding Yannan,Ma Honghong,Xu Yasha,Yang Feng,Li Yi,Shi Fuguo,Lu Yuanfu

Funder

Guizhou Province Department of Education

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference55 articles.

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2. Investigation of the hepatotoxicity of flutamide: pro-survival/apoptotic and necrotic switch in primary rat hepatocytes characterized by metabolic and transcriptomic profiles in microfluidic liver biochips;Audrey;Toxicol. Vitro,2014

3. Androgen deprivation therapy for prostate cancer;Bahnson;J. Urol.,2007

4. Identification of the additional mitochondrial liabilities of 2-hydroxyflutamide when compared with its parent compound, flutamide in HepG2 cells;Ball;Toxicol. Sci.,2016

5. Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies;Berson;J. Pharmacol. Exp. Therapeut.,1993

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