Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

Author:

Stebbins Charles E,Russo Alicia A,Schneider Christine,Rosen Neal,Hartl F.Ulrich,Pavletich Nikola P

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference61 articles.

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2. Helix geometry in proteins;Barlow;J. Mol. Biol.,1988

3. Bohen, S.P., and Yamamoto, K.R. (1994). The Biology of Heat Shock Proteins and Molecular Chaperones, R.I. Morimoto, A. Tissieres and C. Georgopoulos, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).

4. Isolation of Hsp90 mutants by screening for decreased steroid receptor function;Bohen;Proc. Natl. Acad. Sci. USA,1993

5. hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures;Borkovich;Mol. Cell. Biol.,1989

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