Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis

Author:

Zhang Qianqian,Sun Hong,Zhuang Shougang,Liu Na,Bao Xiaowei,Liu Xiandong,Ren Huijuan,Lv Diyu,Li Zhe,Bai Jianwen,Zhou Xiaohui,Tang Lunxian

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Key Discipline Construction Project of Pudong Health Bureau of Shanghai

Ministry of Science and Technology of the People's Republic of China

Top-level Clinical Discipline Project of Shanghai Pudong

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference22 articles.

1. What is sepsis? What is severe sepsis? What is septic shock? Searching for objective definitions among the winds of doctrines and wild theories;Gaieski;Expert Rev. Anti-Infect. Ther.,2013

2. Publication of secondary analyses from randomized trials in critical care;Ramanan;N. Engl. J. Med.,2016

3. The role of epigenetic alterations involved in sepsis: an overview;Hassan;Curr. Pharm. Des.,2018

4. Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury;Thangavel;J. Cell Sci.,2015

5. Histone methylation: a dynamic mark in health, disease and inheritance;Greer;Nat. Rev. Genet.,2012

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