SPH7854, a gut-limited RORγt antagonist, ameliorates TNBS-induced experimental colitis in rat

Author:

Xiang Zhijun,Zhang Bingbin,Cao Shuangyi,Cao Long,Li Lingwen,huang Dehua,Li Qian,Chen Yuxiang,Gong Xuelian,Zhang Xiaohong,Li Ruizhi,Wu Jinmiao,Peng Yayuan,Huo Guoyong,Xu Lixia,Zhang Zhihui,Li Di,Xia GuangxinORCID

Funder

Central Public Research Institutes Basic Funds for Research and Development

Shanghai Aircraft Manufacturing Company

Publisher

Elsevier BV

Reference63 articles.

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2. The global burden of IBD: from 2015 to 2025;Kaplan;Nat. Rev. Gastroenterol. Hepatol.,2015

3. Recent advances in the treatment of IBD: Targets, mechanisms and related therapies;Liu;Cytokine Growth Factor Rev.,2023

4. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells;Ivanov;Cell,2006

5. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22;Takatori;J. Exp. Med.,2009

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