Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats

Author:

Yata M.,McLachlan A.J.,Foster D.J.R.,Hanzlicek A.S.,Beijerink N.J.ORCID

Funder

Thea Jean Schnakenberg Bequest

J.M & J.R. Stewart Legacy

Margot Roslyn Flood Bequest

Luoda Pharma

Publisher

Elsevier BV

Subject

General Veterinary,Physiology

Reference56 articles.

1. UD-CG 115 - a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle;Honerjäger;Naunyn Schmiedebergs Arch Pharmacol,1984

2. Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H )- pyridazinone;Rüegg;Arzneimittelforschung,1984

3. Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts;Berger;Arzneimittelforschung,1985

4. Sensitization of dog and guinea pig heart myofilaments to Ca2+ activation and the inotropic effect of pimobendan: comparison with milrinone;Fujino;Circ Res,1988

5. Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart;Brunkhorst;Naunyn Schmiedebergs Arch Pharmacol,1989

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