Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

Author:

Hu Yue,Gui Zhipeng,Zhou Yuning,Xia Lunguo,Lin Kaili,Xu Yuanjin

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Shanghai Rising-Star Program

Medical and Health Sciences in Shanghai

Program of Shanghai Academic/Technology Research Leader

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference65 articles.

1. Osteoarthritis;Hunter;Lancet,2019

2. Yet more evidence that osteoarthritis is not a cartilage disease;Brandt;Ann. Rheum. Dis.,2006

3. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis;Bondeson;Arthritis Rheum.,2010

4. Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences;Stout;J. Immunol.,2005

5. Macrophage activation switching: an asset for the resolution of inflammation;Porcheray;Clin. Exp. Immunol.,2005

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