Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Author:

Moloney Aileen M.,Griffin Rebecca J.,Timmons Suzanne,O’Connor Rosemary,Ravid Rivka,O’Neill Cora

Publisher

Elsevier BV

Subject

Geriatrics and Gerontology,Developmental Biology,Neurology (clinical),Aging,General Neuroscience

Reference63 articles.

1. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain;Aberg;Sci. World J.,2006

2. Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP+PS1 transgenic mouse brains;Amritraj;Neurobiol. Aging,2007

3. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease;An;Am. J. Pathol.,2003

4. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice;Benzing;Neurobiol. Aging,1999

5. Neuropathological staging of Alzheimer-related changes;Braak;Acta Neuropathol. (Berl.),1991

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