Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function
Author:
Publisher
Oxford University Press (OUP)
Subject
Gastroenterology,General Medicine
Link
http://academic.oup.com/ecco-jcc/article-pdf/6/6/655/1083280/6-6-655.pdf
Reference18 articles.
1. Thiopurines in inflammatory bowel disease — the role of pharmacogenetics and therapeutic drug monitoring;Lindqvist;Curr Pharmacogenet,2006
2. Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come;Ford;J Clin Pathol,2010
3. Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus;Relling;J Natl Cancer Inst,1999
4. Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23;Lindqvist;Pharmacogenet Genomics,2007
5. Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2–*24);Ujiie;Pharmacogenet Genomics,2008
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