The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: Kinetic study following multiple exposures of a pyrrolizidine alkaloid containing extract of Gynura japonica

Author:

Chen Yan,Xiong Fen,Wang Weiqian,Jiang Kaiyuan,Ye Xuanling,Deng Gang,Wang Changhong,Yang Li,Xiong AizhenORCID,Wang ZhengtaoORCID

Funder

National Nature Science Foundation of China

Shanghai Nature Science Foundation

Shanghai Rising-Star Program

Program of Shanghai Academic/Technology Research Leader

Program of Shanghai Municipal Commission of Health and Family Planning

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference42 articles.

1. A simple procedure for determining the aqueous half-lives of pyrrolic metabolites of pyrrolizidine alkaloids;Cooper;Toxicon.,1996

2. The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity;Cooper;Proc. West. Pharmacol. Soc.,1999

3. Expert consensus on diagnosis and treatment of pyrrolidine alkaloids-related sinusoidal obstruction syndrome;Cooperative Group for Hepatic and Gall Diseases;J Clin Hepatol.,2017

4. Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature;Dai;World J. Gastroenterol.,2007

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