ROS generation and MAPKs activation contribute to the Ni-induced testosterone synthesis disturbance in rat Leydig cells

Author:

Han Aijie,Zou Lingyue,Gan Xiaoqin,Li Yu,Liu Fangfang,Chang Xuhong,Zhang Xiaotian,Tian Minmin,Li Sheng,Su Li,Sun Yingbiao

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference58 articles.

1. Aflatoxin B 1 disrupts the androgen biosynthetic pathway in rat Leydig cells;Adedara;Food Chem. Toxicol.,2014

2. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene;Aiba;J. Invest. Dermatol.,2003

3. Reproductive impacts and physiological adaptations of zebrafish to elevated dietary nickel;Alsop;Comp. Biochem. Physiol. C Toxicol. Pharmacol.,2014

4. Protective effects of gallic acid against NiSO4-induced toxicity through down-regulation of the Ras/ERK signaling pathway in beas-2B cells;An;Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.,2016

5. Signal transduction via the MAP kinases: proceed at your own RSK;Blenis;Proc. Natl. Acad. Sci. U. S. A.,1993

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