Estimation of acute oral toxicity using the No Observed Adverse Effect Level (NOAEL) from the 28 day repeated dose toxicity studies in rats

Author:

Bulgheroni Anna,Kinsner-Ovaskainen Agnieszka,Hoffmann Sebastian,Hartung Thomas,Prieto Pilar

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference11 articles.

1. ACuteTox––optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity;Clemedson;ALTEX,2006

2. European Commission, 1967. Council Directive 67/548/EEC of 18 August 1967 on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances. Official Journal of European Communities, L96/1. Office for Official Publications of the European Communities, Luxembourg.

3. European Commission, 2003. Directive 2003/15/EC of the European parliament and the council of 27 February amending Directive 76/786/EEC on the approximation of the laws of the member states relating to cosmetic products. Official Journal of the European Communities L66, 26–35. Office for Official Publications of the European Communities, Luxembourg.

4. European Commission, 2007. Proposal for a regulation of the European parliament and of the council on classification, labelling and packaging of substances and mixtures, and amending Directive 67/548/EEC and Regulation (EC) No 1907/2006.

5. National Institutes of Health (NIH), 2006a. Background Review Document (BRD): Validation of Neutral Red Uptake Test Methods. Publication No. 07-4518, November. Available from: .

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