GPCR desensitization: Acute and prolonged phases

Author:

Rajagopal Sudarshan,Shenoy Sudha K.

Funder

NIH

American Heart Association

Burroughs Wellcome Career Award for Medical Scientists

Publisher

Elsevier BV

Subject

Cell Biology

Reference113 articles.

1. A brief history of G-protein coupled receptors (Nobel lecture);Lefkowitz;Angew. Chem.,2013

2. Role of endocytosis in mediating downregulation of G-protein-coupled receptors;Tsao;Trends Pharmacol. Sci.,2001

3. Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level;Bouvier;J. Biol. Chem.,1989

4. Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration;Campbell;Mol. Pharmacol.,1991

5. Association of sequestered beta-adrenergic receptors with the plasma membrane: a novel mechanism for receptor down regulation;Strader;Life Sci.,1984

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