GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation

Author:

Tu Xian-kun,Chen Ping-ping,Chen Jing-yi,Ding Yi-hang,Chen Quan,Shi Song-sheng

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Pharmacology

Reference61 articles.

1. NLRP3 Inflammasome in Ischemic Stroke: as Possible Therapeutic Target;Alishahi,2019

2. Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues-Liraglutide and Semaglutide;Basalay,2019

3. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination;Bederson;Stroke,1986

4. Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke;Chen;J. Neuroinflammation,2017

5. Liraglutide activates the Nrf2/HO-1 antioxidant pathway and protects brain nerve cells against cerebral ischemia in diabetic rats;Deng;Comput. Intell. Neurosci.,2018

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