Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P

Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)

Published:1999-05 Issue:5 Volume:34 Page:381-387
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Sui Zhihua,Nguyen Van N,Altom Jason,Fernandez Jeffrey,Hilliard Jamese J,Bernstein Jeffrey I,Barrett John F,Ohemeng Kwasi A

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference28 articles.

1. DNA TOPOISOMERASES

2. DNA Topoisomerases: Essential Enzymes and Lethal Targets

3. Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

4. Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

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