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A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice

  • Published:2018-02 Issue: Volume:100 Page:202-211
  • ISSN:0196-9781
  • Container-title:Peptides
  • language:en
  • Short-container-title:Peptides

Author:

Hasib Annie,Ng Ming T.,Khan Dawood,Gault Victor A.,Flatt Peter R.,Irwin Nigel

Funder

University of Ulster Vice-Chancellor Research Scholarship

European Foundation for the Study of Diabetes/Sanofi Programme

Invest Northern Ireland Proof of Concept

Publisher

Elsevier BV

Subject

Cellular and Molecular Neuroscience,Endocrinology,Physiology,Biochemistry

Reference69 articles.

1. The role of gastrointestinal hormones in the pathogenesis of obesity and type 2 diabetes;Adamska;Przeglad Gastroenterologiczny,2014

2. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents;Arakawa;Biochem. Biophys. Res. Commun.,2009

3. Biology of incretins: GLP-1 and GIP;Baggio;Gastroenterology,2007

4. Central action of xenin affects the expression of lipid metabolism-related genes and proteins in mouse white adipose tissue;Bhavya;Neuropeptides,2017

5. Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data;Brown;Pediatr. Diabetes,2008

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