CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway

Author:

van Rooyen Desmaré,Yadav Rahul,Scott Emily E.,Swart Amanda C.

Funder

South African National Research Foundation

Stellenbosch University

University of Michigan

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference50 articles.

1. Profiles of 21-carbon steroids in 21-hydroxylase deficiency;Turcu;J. Clin. Endocrinol. Metab.,2015

2. Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency;Turcu;Eur. J. Endocrinol.,2016

3. Increased activation of the alternative ‘backdoor’ pathway in patients with 21-hydroxylase deficiency: evidence from urinary steroid hormone analysis;Kamrath;J. Clin. Endocrinol. Metab.,2012

4. A liquid chromatography/tandem mass spectometry profile of 16 serum steroids, including 21-deoxycortisol and 21-deoxycorticosterone, for management of congenital adrenal hyperplasia;Fiet;J. Endodrine Soc.,2017

5. Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone;Homma;J. Clin. Endocrinol. Metab.,2006

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