Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure–activity relationships

Author:

Ye Min,Qu Guiqin,Guo Hongzhu,Guo Dean

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Endocrinology,Molecular Biology,Molecular Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference35 articles.

1. Bufadienolides from animal and plant sources;Krenn;Phytochemistry,1998

2. Bufadienolides of plant and animal origin;Steyn;Nat. Prod. Rep.,1998

3. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch’an Su;Nogawa;J. Nat. Prod.,2001

4. Bufalin as a potent inducer of differentiation of human myeloid leukemia cells;Zhang;Biochem. Biophys. Res. Commun.,1991

5. Induction by bufalin of differentiation of human leukemia cells HL60, U937, and ML1 toward macrophage/monocyte-like cells and its potent synergistic effect on the differentiation of human leukemia cells in combination with other inducers;Zhang;Cancer Res.,1992

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