Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo

Author:

Messner Barbara,Zeller Iris,Ploner Christian,Frotschnig Sandra,Ringer Thomas,Steinacher-Nigisch Anneliese,Ritsch Andreas,Laufer Günther,Huck Christian,Bernhard David

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference29 articles.

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2. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose;Lu;Biochem Pharmacol,2007

3. Pharmacological modification of endogenous antioxidant enzymes by ursolic acid on tetrachloride-induced liver damage in rats and primary cultures of rat hepatocytes;Martin-Aragon;Exp Toxicol Pathol,2001

4. Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells;Achiwa;Oncol Rep,2005

5. Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells;Choi;Int J Oncol,2000

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