Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice

Author:

Braun Anne,Yesilaltay Ayce,Acton Susan,Broschat Kay O.,Krul Elaine S.,Napawan Nida,Stagliano Nancy,Krieger Monty

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference34 articles.

1. Clinical review 141: lipids and atherosclerosis: lessons learned from randomized controlled trials of lipid lowering and other relevant studies;Kreisberg;J Clin Endocrinol Metab,2002

2. Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia;Burnett;Expert Opin Investig Drugs,2006

3. In vivo metabolism-based discovery of a potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolites of SCH48461;van Heek;J Pharmacol Exp Ther,1997

4. Discovery of 1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): a designed, potent, orally active inhibitor of cholesterol absorption;Rosenblum;J Med Chem,1998

5. Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: an overview;Gazi;Expert Opin Ther Targets,2006

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