COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author:

Hall Victoria Jane,Foulkes Sarah,Saei Ayoub,Andrews Nick,Oguti Blanche,Charlett Andre,Wellington Edgar,Stowe Julia,Gillson Natalie,Atti Ana,Islam Jasmin,Karagiannis Ioannis,Munro Katie,Khawam Jameel,Chand Meera A,Brown Colin S,Ramsay Mary,Lopez-Bernal Jamie,Hopkins Susan,Andrews N,Atti A,Aziz H,Brooks T,Brown CS,Camero D,Carr C,Chand MA,Charlett A,Crawford H,Cole M,Conneely J,D'Arcangelo S,Ellis J,Evans S,Foulkes S,Gillson N,Gopal R,Hall L,Hall VJ,Harrington P,Hopkins S,Hewson J,Hoschler K,Ironmonger D,Islam J,Kall M,Karagiannis I,Kay O,Khawam J,King E,Kirwan P,Kyffin R,Lackenby A,Lattimore M,Linley E,Lopez-Bernal J,Mabey L,McGregor R,Miah S,Monk EJM,Munro K,Naheed Z,Nissr A,O'Connell AM,Oguti B,Okafor H,Organ S,Osbourne J,Otter A,Patel M,Platt S,Pople D,Potts K,Ramsay M,Robotham J,Rokadiya S,Rowe C,Saei A,Sebbage G,Semper A,Shrotri M,Simmons R,Soriano A,Staves P,Taylor S,Taylor A,Tengbe A,Tonge S,Vusirikala A,Wallace S,Wellington E,Zambon M,Corrigan D,Sartaj M,Cromey L,Campbell S,Braithwaite K,Price L,Haahr L,Stewart S,Lacey ED,Partridge L,Stevens G,Ellis Y,Hodgson H,Norman C,Lacey ED,Larru B,Mcwilliam S,Roynon A,Northfield J,Winchester S,Cieciwa P,Pai A,Bakker P,Loughrey C,Watt A,Adair F,Hawkins A,Grant A,Temple-Purcell R,Howard J,Slawson N,Subudhi C,Davies S,Bexley A,Penn R,Wong N,Boyd G,Rajgopal A,Arenas-Pinto A,Matthews R,Whileman A,Laugharne R,Ledger J,Barnes, T,Jones C,Osuji N,Chitalia N,Bailey T,Akhtar S,Harrison G,Horne S,Walker N,Agwuh K,Maxwell V,Graves J,Williams S,O'Kelly A,Ridley P,Cowley A,Johnstone H,Swift P,Democratis J,Meda M,Brake S,Gunn J,Selassi A,Hams S,Irvine V,Chandrasekaran B,Forsyth C,Radmore J,Thomas C,Brown K,Roberts S,Burns P,Gajee K,Lewis T,Byrne TM,Sanderson F,Knight S,Macnaughton E,Burton BJL,Smith H,Chaudhuri R,Aeron-Thomas J,Hollinshead K,Shorten RJ,Swan A,Shorten RJ,Favager C,Murira J,Baillon S,Hamer S,Shah A,Russell J,Brennan D,Dave A,Chawla A,Westwell F,Adeboyeku D,Papineni P,Pegg C,Williams M,Ahmad S,Horsley A,Gabriel C,Pagget K,Cieciwa P,Maloney G,Ashcroft J,Del Rosario I,Crosby-Nwaobi R,Flanagan D,Dhasmana D,Fowler S,Cameron E,Prentice L,Sinclair C,Irvine V,Bateman V,McLelland-Brooks K,Ho A,Murphy M,Cochrane A,Gibson A,Patel M,Black K,Tempeton K,Donaldson S,Coke L,Elumogo N,Elliott J,Padgett D,Cross A,Mirfenderesky M,Joyce S,Sinanovic I,Howard M,Lewis T,Cowling P,Brazil M,Hanna E,Abdelrazik A,Brand S,Sheridan EA,Wadams B,Lloyd A,Mouland J,Giles J,Pottinger G,Coles H,Joseph M,Lee M,Orr S,Chenoweth H,Browne D,Auckland C,Lear R,Mahungu T,Rodger A,Warren S,Brooking D,Pai S,Druyeh R,Smith E,Stone S,Meisner S,Delgado D,Underhill E,Keen L,Aga M,Domingos P,Gormley S,Kerrison C,Birch S,DeSilva T,Allsop L,Ambalkar S,Beekes M,Jose S,Tomlinson J,Painter Sharen,Price C,Pepperell J,James K,Trinick T,Moore L,Day J,Boulos A,Knox I,Defever E,McCracken D,Brown K,Gray K,Houston A,Planche T,Pritchard Jones R,Wycherley Diane,Bennett S,Marrs J,Nimako K,Stewart B,Bain SC,Kalakonda N,Khanduri S,Ashby A,Holden M,Mahabir N,Harwood J,Payne B,Court K,White N,Longfellow R,Hughes LE,Green ME,Halkes M,Mercer P,Roebuck A,Wilson-Davies E,Gallego L,Lazarus R,Aldridge N,Berry L,Game F,Reynolds T,Holmes C,Wiselka M,Higham A,Booth M,Duff C,Alderton J,Hilton D,Powell J,Jackson A,Plant AJ,Ahmed N,Chin T,Qazzafi MZ,Moody AM,Tilley RE,Donaghy T,O'Kane M,Shipman K,Sierra R,Parmar C,Mills G,Harvey D,Huang YWJ,Birch J,Robinson L,Board S,Broadley A,Laven C,Todd N,Eyre DW,Jeffery K,Dunachie S,Duncan C,Klenerman P,Turtle L,Baxendale H,Heeney JL

Funder

United Kingdom Department of Health and Social Care

Public Health England

National Institute for Health Research

Publisher

Elsevier BV

Subject

General Medicine

Reference19 articles.

1. A review of the progress and challenges of developing a vaccine for COVID-19;Sharma;Front Immunol,2020

2. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK;Voysey;Lancet,2021

3. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine;Polack;N Engl J Med,2020

4. Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020;Hall;medRxiv,2021

5. SIREN protocol: Impact of detectable anti-SARS-CoV-2 on the subsequent incidence of COVID-19 in 100,000 healthcare workers: do antibody positive healthcare workers have less reinfection than antibody negative healthcare workers?;Wallace;medRxiv,2020

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