Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis

Author:

Tang Jian-Min,He Quan-Ying,Guo Rui-Xia,Chang Xiu-Jun

Publisher

Elsevier BV

Subject

Cancer Research,Pulmonary and Respiratory Medicine,Oncology

Reference41 articles.

1. American cancer society surveillance research. Cancer facts and figures 2004. Atlanta (GA): American cancer society; 2004:1–60.

2. The phosphatidylinositol 3-kinase AKT pathway in human cancer;Vivanco;Nat Rev Cancer,2002

3. Akt/protein kinase B is constitutively active in non-small cell lung cancer and promotes cellular survival and resistance to chemotherapy and radiation;Brognard;Cancer Res,2001

4. Protein kinase B(c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation;Coffer;Biochem J,1998

5. New insights into tumor suppression: PTEN suppression tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway;Cantley;PNAS,1999

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