Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2

Author:

Su Mingze,Xiang KuanhuiORCID,Li Yao,Li Yutang,Deng Juan,Xu Xizhan,Yan Ling,Zhuang Hui,Li Tong

Funder

Major Science and Technology Special Project of China Thirteenth Five-year Plan

Twelfth Five-year Plan

Publisher

Elsevier BV

Subject

Infectious Diseases,Microbiology (medical),Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics,Microbiology

Reference35 articles.

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2. Mutations that change the immunological subtype of hepatitis B virus surface antigen and distinguish between antigenic and immunogenic determination;Ashton-Rickardt;J. Med. Virol.,1989

3. Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations;Bartholomeusz;Antivir. Ther.,2004

4. Unveiling the roles of HBV polymerase for new antiviral strategies;Clark;Futur. Virol.,2015

5. High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus;De Maddalena;Virology,2007

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