Ginsenoside CK targeting KEAP1-DGR/Kelch domain disrupts the binding between KEAP1 and NRF2-DLG motif to ameliorate oxidative stress damage
Author:
Funder
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine
Reference49 articles.
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2. FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding;Cheng;EBioMedicine,2019
3. Astragaloside IV targets PRDX6, inhibits the activation of RAC subunit in NADPH oxidase 2 for oxidative damage;Cheng;Phytomedicine,2023
4. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease;Dayalan Naidu;Open Biol.,2020
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