Targeted metabolomics reveals PFKFB3 as a key target for elemene-mediated inhibition of glycolysis in prostate cancer cells

Author:

Dong Xue-Man,Chen Lin,Wu Pu,Cheng Long-Hui,Wang Yu,Yang Youjian,Zhang Yongwei,Tang Wei-Yang,Xie Tian,Zhou Jian-LiangORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine

Reference58 articles.

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2. High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (ipfk-2; pfkfb3) in human cancers1;Atsumi;Cancer Res.,2002

3. Anti-tumor drug discovery based on natural product β-elemene: anti-tumor mechanisms and structural modification;Bai;Molecules,2021

4. Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/pfkfb3 family of glycolytic regulators in human cancer;Bando;Clin. Cancer Res.,2005

5. The metabolism of cancer cells during metastasis;Bergers;Nat. Rev. Cancer,2021

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