Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements-Reference-Cited by-同舟云学术

Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: Examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements

Published:2006-03-01 Issue:3 Volume:17 Page:363-375
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Peterman Scott M.¹,Duczak Nicholas¹,Kalgutkar Amit S.²,Lame Mary E.²,Soglia John R.²

Affiliation:

1. Thermo Electron Corporation, Somerset, New Jersey, USA

2. Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Eastern Point Road, 06340, Groton, CT, USA

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1016/j.jasms.2005.11.014

Reference21 articles.

1. Minimising the potential for metabolic activation in drug discovery

2. Strategies for characterization of drug metabolites using liquid chromatography–tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches

3. Elucidation of fragmentation mechanisms involving transfer of three hydrogen atoms using a quadrupole time-of-flight mass spectrometer

4. A Novel P450-Catalyzed Transformation of the 2,2,6,6-Tetramethyl Piperidine Moiety to a 2,2-Dimethyl Pyrrolidine in Human Liver Microsomes: Characterization by High Resolution Quadrupole-Time-of-Flight Mass Spectrometry and 1H-NMR

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