Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design-Reference-Cited by-同舟云学术

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Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design

Published:2019-02 Issue: Volume:164 Page:334-341
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Ji Dezhong,Zhang Lingzhi,Zhu Qihua,Bai Ying,Wu Yaoyao,Xu Yungen

Funder

Outstanding Scientific and Technological Innovation Team Projects of Jiangsu Province, China

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference21 articles.

1. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides;Schirmer;Proc. Natl. Acad. Sci. U.S.A.,2006

2. MAP kinase signaling pathways in cancer;Dhillon;Oncogene,2007

3. The hallmarks of cancer;Hanahan;Cell,2000

4. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions;Yoon;Growth Factors,2006

5. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases;Owens;Oncogene,2007

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1. Design, Synthesis, and Antibacterial Evaluation of Novel Isoindolin-1-ones Derivatives Containing Piperidine Fragments;Journal of Agricultural and Food Chemistry;2024-05-22

2. Molecular medicinal insights into scaffold hopping-based drug discovery success;Drug Discovery Today;2024-01

3. Design, synthesis and biological evaluation of novel 4-aminopiperidine derivatives as SMO/ERK dual inhibitors;Bioorganic & Medicinal Chemistry;2022-11

4. Targeting Extracellular Signal-Regulated Protein Kinase 1/2 (ERK1/2) in Cancer: An Update on Pharmacological Small-Molecule Inhibitors;Journal of Medicinal Chemistry;2022-10-07

5. An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint;Mini-Reviews in Medicinal Chemistry;2022-10

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